MovDisordV3, France, Analysis, bibRecord, 000351

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Identifieur interne : 000351 ( France/Analysis ); précédent : 000350; suivant : 000352

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Auteurs : Fabienne Ory-Magne [France] ; Christine Brefel-Courbon [France] ; Marion Simonetta-Moreau [France] ; Nelly Fabre [France] ; Jean Albert Lotterie [France] ; Patrick Chaynes [France] ; Isabelle Berry [France] ; Yves Lazorthes [France] ; Olivier Rascol [France]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0393267

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Vieillissement, Pronostic, Noyau sousthalamique, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Ageing, Deep brain stimulation, Nervous system diseases, Parkinson disease, Prognosis, Subthalamic nucleus.

Abstract

We sought to define the influence of ageing in clinical, cognitive, and quality-of-life outcomes after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We performed motor assessment (UPDRS), mood tests, cognitive, and quality of life evaluation (PDQ-39) on PD patients before surgery, and 12 and 24 months after, and we recorded adverse events. The variations of these parameters after surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a nonparametric test. We enrolled 45 patients (mean age 60 ± 9 years, range 40-73). No significant correlation was found between age and motor scores and PDQ-39 improvements at 12 months. At 24 months, there was a significant negative correlation between age and the improvement of three dimensions of PDQ 39 (mobility, activities of daily life, and cognition). Cognitive impairment showed no correlation, but apathy and depression were positively correlated with age. Significant statistical difference was observed between cerebral bleeding and age. STN-DBS is an effective treatment for elderly patients with advanced PD. A longer follow-up duration and a larger population seem necessary to better assess the quality of life perception in elderly patients and to determinate the real risk of hemorrage.

Affiliations:

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Pascal:07-0393267

Le document en format XML

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<term>Deep brain stimulation</term>
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<term>Subthalamic nucleus</term>
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<term>Parkinson maladie</term>
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<front><div type="abstract" xml:lang="en">We sought to define the influence of ageing in clinical, cognitive, and quality-of-life outcomes after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We performed motor assessment (UPDRS), mood tests, cognitive, and quality of life evaluation (PDQ-39) on PD patients before surgery, and 12 and 24 months after, and we recorded adverse events. The variations of these parameters after surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a nonparametric test. We enrolled 45 patients (mean age 60 ± 9 years, range 40-73). No significant correlation was found between age and motor scores and PDQ-39 improvements at 12 months. At 24 months, there was a significant negative correlation between age and the improvement of three dimensions of PDQ 39 (mobility, activities of daily life, and cognition). Cognitive impairment showed no correlation, but apathy and depression were positively correlated with age. Significant statistical difference was observed between cerebral bleeding and age. STN-DBS is an effective treatment for elderly patients with advanced PD. A longer follow-up duration and a larger population seem necessary to better assess the quality of life perception in elderly patients and to determinate the real risk of hemorrage.</div>
</front>
</TEI>
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<tree><country name="France"><noRegion><name sortKey="Ory Magne, Fabienne" sort="Ory Magne, Fabienne" uniqKey="Ory Magne F" first="Fabienne" last="Ory-Magne">Fabienne Ory-Magne</name>
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<name sortKey="Berry, Isabelle" sort="Berry, Isabelle" uniqKey="Berry I" first="Isabelle" last="Berry">Isabelle Berry</name>
<name sortKey="Brefel Courbon, Christine" sort="Brefel Courbon, Christine" uniqKey="Brefel Courbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
<name sortKey="Chaynes, Patrick" sort="Chaynes, Patrick" uniqKey="Chaynes P" first="Patrick" last="Chaynes">Patrick Chaynes</name>
<name sortKey="Fabre, Nelly" sort="Fabre, Nelly" uniqKey="Fabre N" first="Nelly" last="Fabre">Nelly Fabre</name>
<name sortKey="Lazorthes, Yves" sort="Lazorthes, Yves" uniqKey="Lazorthes Y" first="Yves" last="Lazorthes">Yves Lazorthes</name>
<name sortKey="Lotterie, Jean Albert" sort="Lotterie, Jean Albert" uniqKey="Lotterie J" first="Jean Albert" last="Lotterie">Jean Albert Lotterie</name>
<name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
<name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri